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Molecular Biology of the SARS-Coronavirus – Sunil K. Lal

Titulo del libro: Molecular Biology of the SARS-Coronavirus

Autor del libro: Sunil K. Lal

Formato de libro: EBook

Date published: 2010

Illustrator: Springer

ISBN: 978-3-642-03682-8

Número de páginas: 330

Libros de Medicina – Rincón Médico

Molecular Biology of the SARS-Coronavirus

The SARS outbreak took the whole world by surprise in November 2002. It was the most unprecedented epidemic outbreak in recorded history and the first major new infectious disease of this century, unusual in its high morbidity and mortality rates and in strategically taking advantage of modern international travel to propagate itself around the world. What followed was a global havoc created by this disease, bringing the healthcare system of affected areas to a grinding halt, affecting healthcare providers, disrupting scheduled emergency surgeries and vital treatment to patients with serious conditions, overloading hospitals with infected cases, forcing public events to be cancelled, and schools, and borders to be closed. The economic impact on individuals and businesses was profound, downregulating tourism, education, and employment.
The epidemic was completely different from all known traditional atypical types of pneumonia because patients experienced lack of oxygen at the onset of the disease and hence required the aid of modern respiratory equipment to breathe. This syndrome was contagious enough to infect a substantial number of people widely and easily. In our days of medical advancement and high technology, which has subsequently led to increased life spans and longevity, a growing confidence had emerged in mankind that it had now achieved the ability to overcome the most complicated life-threatening situations. SARS shattered this confidence and made us realize once again that there are hundreds of dangerous and virulent microorganisms living on the other side of the border that can kill humans. What separates us from them is only the species barrier.

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Part I: Viral Entry
  • 1. Cellular Entry of the SARS Coronavirus: Implications for Transmission, Pathogenicity and Antiviral Strategies
  • 2. The Cell Biology of the SARS Coronavirus Receptor, Angiotensin-Converting Enzyme
  • 3. Structural Molecular Insights into SARS Coronavirus Cellular Attachment, Entry and Morphogenesis
Part II: Structures Involved in Viral Replication and Gene Expression
  • 4. RNA Higher-Order Structures Within the Coronavirus 50 and 30 Untranslated Regions and Their Roles in Viral Replication
  • 5. Programmed _1 Ribosomal Frameshifting in SARS Coronavirus
Part III: Viral Proteins
  • 6. Expression and Functions of SARS Coronavirus Replicative Proteins
  • 7. SARS Coronavirus Replicative Enzymes: Structures and Mechanisms
  • 8. Quaternary Structure of the SARS Coronavirus Main Protease
  • 9. The Nucleocapsid Protein of the SARS Coronavirus: Structure, Function and Therapeutic Potential
  • 10. SARS Coronavirus Accessory Gene Expression and Function
  • 11. SARS Accessory Proteins ORF3a and 9b and Their Functional Analysis
  • 12. Molecular and Biochemical Characterization of the SARS-CoV Accessory Proteins ORF8a, ORF8b and ORF8ab
Part IV: Viral Pathogenesis and Host Immune Response
  • 13. SARS Coronavirus Pathogenesis and Therapeutic Treatment Design
  • 14. Modulation of Host Cell Death by SARS Coronavirus Proteins
  • 15. SARS Coronavirus and Lung Fibrosis
  • 16. Host Immune Responses to SARS Coronavirus in Humans
  • 17. The Use of Retroviral Pseudotypes for the Measurement of Antibody Responses to SARS Coronavirus
  • 18. SARS Coronavirus Spike Protein Expression in HL-CZ Human Promonocytic Cells: Monoclonal Antibody and Cellular Transcriptomic Analyses
  • 19. Signaling Pathways of SARS-CoV In Vitro and In Vivo
  • Index
Anatomia Biologia Cardiologia Cirugia Enfermeria Farmacología Fisiología Ginecología Odontologia Oncología Otros Pediatría Psicología
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