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Rang and Dale’s Pharmacology 9th edition

Titulo del libro: Rang and Dale’s Pharmacology

Autor del libro: James Ritter, Rod Flower, Graeme Henderson, Yoon Kong Loke, David MacEwan, Humphrey Rang

Edición de libro: 9th edition

Formato de libro: EBook

Date published: 2020

Illustrator: Elsevier

ISBN: 978-0-7020-7448-6

Número de páginas: 755

Libros de Medicina – Rincón Médico

Rang and Dale’s Pharmacology

In this edition, as in its predecessors, we set out to explain what drugs do in terms of the mechanisms by which they act. This entails analysis not only at the cellular and molecular level, where knowledge and techniques are advancing rapidly, but also at the level of physiological mechanisms and pathological disturbances. Pharmacology has its roots in therapeutics, where the aim is to ameliorate the effects of disease, so we have attempted to make the link between effects at the molecular and cellular level and the range of beneficial and adverse effects that humans experience when drugs are used for therapeutic or other reasons. Therapeutic agents have a high rate of obsolescence. In the decade 2008 to 2017, 301 new drugs gained regulatory approval for use as therapeutic agents. The majority exploit the same molecular targets as drugs already in use. Knowledge of the mechanisms of action of the class of drugs to which a new agent belongs provides a good starting point for understanding and using a new compound intelligently.
Significantly, however, one-third of these new arrivals are ‘first-in-class’ drugs. That is, they act on novel molecular targets not previously exploited for therapeutic purposes, and are therefore likely to produce effects not previously described. Not all will succeed clinically, but some will stimulate the development of improved follow-up compounds of the same type. Furthermore, about a quarter of the new compounds are ‘biopharmaceuticals’ – mainly proteins produced by bioengineering rather than synthetic chemistry. These are growing in importance as therapeutic agents, and generally have characteristics somewhat different from conventional drugs and are covered in a revised chapter.
The very high rate of innovation in drug discovery is a recent – and very welcome – change, due in large part to the rapid advances in molecular and cell biology that have stemmed from the sequencing of the human genome in 2003. We have tried to strike a balance between the need to keep up with these modern developments and the danger of information overload. Our emphasis is on explaining the general principles underlying drug action, which apply to old and new alike, and to describe in more detail the actions and mechanisms of familiar, established drugs, while including references that cover modern and future developments.


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CONTENIDO:

Section 1. General principles
  • 1. What is pharmacology?
  • 2. How drugs act: general principles
  • 3. How drugs act: molecular aspects
  • 4. How drugs act: cellular aspects excitation, contraction and secretion
  • 5. Biopharmaceuticals and gene therapy
  • 6. Cell proliferation, apoptosis, repair and regeneration
  • 7. Cellular mechanisms: host defence
  • 8. Method and measurement in pharmacology
  • 9. Absorption and distribution of drugs
  • 10. Drug metabolism and elimination
  • 11. Pharmacokinetics
  • 12. Individual Variation, Pharmacogenomics and Personalised Medicine
Section 2. Chemical Mediators
  • 13. Chemical mediators and the autonomic nervous system
  • 14. Cholinergic transmission
  • 15. Noradrenergic transmission
  • 16. 5-Hydroxytryptamine and the Pharmacology of Migraine
  • 17. Purines
  • 18. Local Hormones 1: Histamin and the Biologically Active Lipids.
  • 19. Local Hormones 2: Peptides and Proteins
  • 20. Cannabinoids
  • 21. Nitric oxide and other gaseous mediators
Section 3. Drugs affecting major organ systems
  • 22. The heart
  • 23. The vascular system
  • 24. Atherosclerosis and lipid metabolism
  • 25. Haemostasis and thrombosis
  • 26. Haemopoietic system
  • 27. Anti-inflammatory and immunosuppressant drugs
  • 28. Skin
  • 29. Respiratory system
  • 30. The Kidney and urinary system
  • 31. The Gastrointestinal tract
  • 32. The control of blood glucose and drug treatment of diabetes mellitus
  • 33. Obesity
  • 34. The Pituitary and the adrenal cortex
  • 35. Thyroid
  • 36. The reproductive system
  • 37. Bone metabolism
Section 4. Nervous System
  • 38. Chemical transmission and drug action in the nervous system
  • 39. Amino acid transmitters
  • 40. Other transmitters and modulators
  • 41. Neurodegenerative diseases
  • 42. General anaesthetic agents
  • 43. Analgesic drugs
  • 44. Local anaesthetics and other drugs affecting sodium channels
  • 45. Anxiolytic and hypnotic drugs
  • 46. Antiepileptic drugs
  • 47. Antipsychotic drugs
  • 48. Antidepressant drugs
  • 49. CNS stimulants and psychotomimetic drugs
  • 50. Drug addiction, dependence and abuse
Section 5. Drugs used for the treatment of infections and cancer
  • 51. Basic principles of antimicrobial chemotherapy
  • 52. Antibacterial drugs
  • 53. Antiviral drugs
  • 54. Antifungal drugs
  • 55. Antiprotozoal drugs
  • 56. Anthelmintic drugs
  • 57. Anti-cancer drugs
  • Section 6. Special Topics
  • 58. Harmful effects of drugs
  • 59. Lifestyle drugs and drugs in sport
  • 60. Drug discovery and development
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