Molecular Cell Biology 8th Edition – Harvey Lodish y otros

Molecular Cell Biology

In writing the eighth edition of Molecular Cell Biology, we have incorporated many of the spectacular advances made over the past four years in biomedical science, driven in part by new experimental technologies that have revolutionized many fields. Fast techniques for sequencing DNA, allied with efficient methods to generate and study mutations in model organisms and to map disease-causing mutations in
humans, have illuminated a basic understanding of the functions of many cellular components, including hundreds of human genes that affect diseases such as diabetes and cancer.
For example, advances in genomics and bioinformatics have uncovered thousands of novel long noncoding RNAs that regulate gene expression, and have generated insights into and potential therapies for many human diseases.
Powerful genome editing technologies have led to an unprecedented understanding of gene regulation and function in many types of living organisms. Advances in mass spectrometry and cryoelectron microscopy have enabled dynamic cell processes to be visualized in spectacular detail, providing deep insight into both the structure and the function of biological molecules, post-translational modifications, multiprotein complexes, and organelles. Studies of specific nerve cells in live organisms have been advanced by optogenetic technologies. Advances in stem-cell technology have come from studies of the role of stem cells in plant development and of regeneration in planaria.
Exploring the most current developments in the field is always a priority in writing a new edition, but it is also important to us to communicate the basics of cell biology clearly by stripping away as much extraneous detail as possible to focus attention on the fundamental concepts of cell biology.
To this end, in addition to introducing new discoveries and technologies, we have streamlined and reorganized several chapters to clarify processes and concepts for students.