Coronavirus Replication and Reverse Genetics – Luis Enjuanes
Book Title: Coronavirus Replication and Reverse Genetics
Book Author: Luis Enjuanes
Book Format: EBook
Illustrator: Springer
ISBN: 3-540-21494-1
Number Of Pages: 261
Descripción
Coronavirus Replication and Reverse Genetics
The Coronaviridae family is included in the Nidovirales order together with the Arteriviridae and Roniviridae. Possibly the first recorded coronavirus related disease was feline infectious peritonitis in 1912. However, until the late 1960s the coronaviruses were not recognized as pathogens responsible for human diseases (common cold), and it was in 2003 when human coronaviruses (HCoVs) received worldwide attention with the emergence of the severe and acute respiratory syndrome (SARS), produced by a coronavirus (SARS-CoV), that has infected more than 8,000 people in 32 countries, killing about 10%. The increase in research on coronaviruses soon led to the discovery of another human coronavirus (HCoV-NL63), which is prevalent in 7% of hospital patients and has been associated with bronchiolitis and, possibly, conjunctivitis.
Coronaviruses have been identified in mice, rats, chickens, turkeys, pigs, dogs, cats, rabbits, horses, cows, and humans. Coronaviruses are associated mainly with respiratory, enteric, hepatic, and central nervous system diseases. In humans and fowl, coronaviruses primarily cause upper respiratory tract infections, while porcine and bovine coronaviruses establish enteric infections that result in severe economic losses. HCoVs are responsible for 10%–20% of common colds, and have been implicated in gastroenteritis, high and low respiratory tract infections, and rare cases of encephalitis. HCoVs have also been associated with infant necrotizing enterocolitis and are tentative candidates for multiple sclerosis.
The Coronaviridae family is included in the Nidovirales order together with the Arteriviridae and Roniviridae. Possibly the first recorded coronavirus related disease was feline infectious peritonitis in 1912. However, until the late 1960s the coronaviruses were not recognized as pathogens responsible for human diseases (common cold), and it was in 2003 when human coronaviruses (HCoVs) received worldwide attention with the emergence of the severe and acute respiratory syndrome (SARS), produced by a coronavirus (SARS-CoV), that has infected more than 8,000 people in 32 countries, killing about 10%. The increase in research on coronaviruses soon led to the discovery of another human coronavirus (HCoV-NL63), which is prevalent in 7% of hospital patients and has been associated with bronchiolitis and, possibly, conjunctivitis.
Coronaviruses have been identified in mice, rats, chickens, turkeys, pigs, dogs, cats, rabbits, horses, cows, and humans. Coronaviruses are associated mainly with respiratory, enteric, hepatic, and central nervous system diseases. In humans and fowl, coronaviruses primarily cause upper respiratory tract infections, while porcine and bovine coronaviruses establish enteric infections that result in severe economic losses. HCoVs are responsible for 10%–20% of common colds, and have been implicated in gastroenteritis, high and low respiratory tract infections, and rare cases of encephalitis. HCoVs have also been associated with infant necrotizing enterocolitis and are tentative candidates for multiple sclerosis.
