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Rang and Dale’s Pharmacology 8th Edition

Titulo del libro: Rang and Dale’s Pharmacology

Autor del libro: H. P. Rang, J. M. Ritter, R. J. Flower, G. Henderson

Edición de libro: 8th Edition

Formato de libro: EBook

Date published: 2016

Illustrator: Elsevier

ISBN: 13 978-0-7020-5362-7

Número de páginas: 738

Libros de Medicina – Rincón Médico

Rang and Dale’s Pharmacology

In this edition, as in its predecessors, we set out not just to describe what drugs do but also to emphasise the mechanisms by which they act. This entails analysis not only at the cellular and molecular level, where knowledge and techniques are advancing rapidly, but also at the level of physiological mechanisms and pathological disturbances.
Pharmacology has its roots in therapeutics, where the aim is to ameliorate the effects of disease, so we have attempted to make the link between effects at the molecular and cellular level and the range of beneficial and adverse effects that humans experience when drugs are used for therapeutic or other reasons. Therapeutic agents have a high rate of obsolescence, and more than 100 new ones have been approved since the last edition of this book. An appreciation of the mechanisms of action of the class of drugs to which a new agent belongs provides a good starting point for understanding and using a new compound intelligently.
Pharmacology is a lively scientific discipline in its own right, with an importance beyond that of providing a basis for the use of drugs in therapy, and we aim to provide a good background, not only for future doctors but also for scientists in other disciplines who need to understand how drugs act. We have, therefore, where appropriate, described how drugs are used as probes for elucidating cellular and physiological functions, even when the compounds have no clinical use.
Names of drugs and related chemicals are established through usage and sometimes there is more than one name in common use. For prescribing purposes, it is important to use standard names, and we follow, as far as possible, the World Health Organization’s list of recommended
international non-proprietary names (rINN).
Sometimes these conflict with the familiar names of drugs (e.g. amphetamine becomes amfetamine in the rINN list), and the endogenous mediator prostaglandin I2 – the standard name in the scientific literature – becomes ‘epoprostenol’ – a name unfamiliar to most scientists – in the rINN list. In general, we use rINN names as far as possible in the context of therapeutic use, but often use the common name in describing mediators and familiar drugs. Sometimes English and American usage varies (as with adrenaline/epinephrine and noradrenaline/
norepinephrine). Adrenaline and noradrenaline are the official names in EU member states and relate clearly to terms such as ‘noradrenergic’, ‘adrenoceptor’ and ‘adrenal gland’ and we prefer them for these reasons.

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Section 1: General principles
  • 1. What is pharmacology?
  • 2. How drugs act: general principles
  • 3. How drugs act: molecular aspects
  • 4. How drugs act: cellular aspects—excitation, contraction and secretion
  • 5. Cell proliferation, apoptosis, repair and regeneration
  • 6. Cellular mechanisms: host defence
  • 7. Method and measurement in pharmacology
  • 8. Drug absorption and distribution
  • 9. Drug metabolism and elimination
  • 10. Pharmacokinetics
  • 11. Pharmacogenetics, pharmacogenomics and ‘personalised medicine’
Section 2: Chemical mediators
  • 12. Chemical mediators and the autonomic nervous system
  • 13. Cholinergic transmission
  • 14. Noradrenergic transmission
  • 15. 5-Hydroxytryptamine and the pharmacology of migraine
  • 16. Purines
  • 17. Local hormones: cytokines, biologically active lipids, amines and peptides
  • 18. Cannabinoids
  • 19. Peptides and proteins as mediators
  • 20. Nitric oxide
Section 3: Drugs affecting major organ systems
  • 21. The heart
  • 22. The vascular system
  • 23. Atherosclerosis and lipoprotein metabolism
  • 24. Haemostasis and thrombosis
  • 25. Haemopoietic system and treatment of anaemia
  • 26. Anti-inflammatory and immunosuppressant drugs
  • 27. The respiratory system
  • 28. The kidney
  • 29. The gastrointestinal tract
  • 30. The control of blood glucose and drug treatment of diabetes mellitus
  • 31. Obesity
  • 32. The pituitary and the adrenal cortex
  • 33. The thyroid
  • 34. The reproductive system
  • 35. Bone metabolism
Section 4: The nervous system
  • 36. Chemical transmission and drug action in the central nervous system
  • 37. Amino acid transmitters
  • 38. Other transmitters and modulators
  • 39. Neurodegenerative diseases
  • 40. General anaesthetic agents
  • 41. Analgesic drugs
  • 42. Local anaesthetics and other drugs affecting sodium channels
  • 43. Anxiolytic and hypnotic drugs
  • 44. Antiepileptic drugs
  • 45. Antipsychotic drugs
  • 46. Antidepressant drugs
  • 47. CNS stimulants and psychotomimetic drugs
  • 48. Drug addiction, dependence and abuse
Section 5: Drugs used for the treatment of infections, cancer and immunological disorders
  • 49. Basic principles of antimicrobial chemotherapy
  • 50. Antibacterial drugs
  • 51. Antiviral drugs
  • 52. Antifungal drugs
  • 53. Antiprotozoal drugs
  • 54. Anthelminthic drugs
  • 55. Anticancer drugs
Section 6: Special topics
  • 56. Individual variation and drug interaction
  • 57. Harmful effects of drugs
  • 58. Lifestyle drugs and drugs in sport
  • 59. Biopharmaceuticals and gene therapy
  • 60. Drug discovery and development
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