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Rheumatology 6th Edition


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Rheumatology 6th Edition
In this new edition of Rheumatology, the editors have again attempted to bring together a large group of world-renowned authors to provide essential information on the scientific basis of rheumatology and the definition, epidemiology, pathophysiology, clinical features, and management of all arthritic, musculoskeletal, and rheumatic disorders.
Rheumatology, Sixth Edition, builds on the success of the previous editions.

As stated by Professor Jan Dequeker in his review of the fourth edition, “Rheumatology is the most comprehensive, authoritative rheumatology text designed to meet the complete needs of all practicing and academic rheumatologists as well as arthritis-related health care professionals and scientists interested in disorders of the musculoskeletal system. The edition is firmly grounded on modern medical science, integrating the relevant basic biology with current clinical practice, easily accessible, user-friendly, and a beautifully illustrated color publication.”
For this edition, every chapter has either been substantially revised or, in many cases, entirely rewritten, following a rigorous editorial policy to ensure that the content and format of the book remain consistent and meet the highest possible standards. Each chapter has been updated to incorporate a broad range of new information. Fourteen completely new chapters cover biomedical and translational science, disease and outcome assessment, including new imaging modalities and early emerging disease, clinical therapeutics, and patient management and rehabilitation. The text has been streamlined, ensuring that each chapter contains the most critical and current information in the field, while supplemental materials (including extra tables, figures, and bonus text) are conveniently located online.
The index has also been improved, making it easier for the reader to find topics of interest.

CONTENTS:

SECTION 1: THE SCIENTIFIC BASIS OF RHEUMATIC DISEASE
Chapter 1: Epidemiologic concepts and classification of rheumatic and musculoskeletal conditions
Chapter 2: Principles of clinical outcome assessment
Chapter 3: Principles of health economics and application to rheumatic disorders
Chapter 4: The synovium
Chapter 5: Articular cartilage
Chapter 6: Bone structure and function
Chapter 7: Tendons and ligaments
Chapter 8: Connective tissue responses to mechanical stress
Chapter 9: Biomechanics of peripheral joints
Chapter 10: Biomechanics of the spine
Chapter 11: Principles of genetic epidemiology
Chapter 12: Principles and techniques in molecular biology
Chapter 13: Cytokines
Chapter 14: Signal transduction in immune cells
Chapter 15: Principles of adaptive immunity
Chapter 16: Principles of innate immunity
Chapter 17: Systems biology
Chapter 18: Epigenetics in rheumatology
Chapter 19: The microbiome in rheumatic diseases
Chapter 20: Tissue destruction and repair
Chapter 21: Principles of tissue engineering and cell- and gene-based therapy
Chapter 22: Osteoimmunology
Chapter 23: Inflammation and its mediators
Chapter 24: Scientific basis of pain
Chapter 25: Effects of the neuroendocrine system on development and function of the immune system
Chapter 26: Interpreting the medical literature for the rheumatologist: Study design and levels of evidence
Chapter 27: Ethics in clinical trials

SECTION 2: CLINICAL BASIS OF RHEUMATIC DISEASE
Chapter 28: History and physical examination
Chapter 29: Pattern recognition in arthritis
Chapter 30: Role of laboratory tests in rheumatic disorders
Chapter 31: Synovial fluid analysis
Chapter 32: Minimally invasive procedures
Chapter 33: Skin in rheumatic disease
Chapter 34: The eye in rheumatic disease
Chapter 35: The heart in rheumatic disease
Chapter 36: The lung in rheumatic disease
Chapter 37: Gastrointestinal tract and rheumatic disease
Chapter 38: The kidney and rheumatic disease
Chapter 39: The nervous system in rheumatic disease

SECTION 3: EVALUATION: IMAGING TECHNIQUES
Chapter 40: Conventional radiography and computed tomography
Chapter 41: Functional magnetic resonance imaging
Chapter 42: Musculoskeletal ultrasound
Chapter 43: Bone scintigraphy and positron emission tomography
Chapter 44: Dual x-ray absorptiometry and measurement of bone
Chapter 45: Use of imaging as an outcome measure in rheumatoid arthritis, psoriatic arthritis, and ankylosing spondylitis in clinical trials

SECTION 4: PRINCIPLES OF MANAGEMENT
Chapter 46: Arthritis patient education, health promotion, and team approaches to management
Chapter 47: Principles of rehabilitation: Physical and occupational therapy
Chapter 48A: Complementary and alternative medicine
Chapter 48B: Placebos, caring, and healing in rheumatology
Chapter 49: Drug development
Chapter 50: Nonpharmacologic pain management
Chapter 51: Pharmacogenomics in rheumatology
Chapter 52: Principles of opioid treatment of chronic musculoskeletal pain
Chapter 53: Nonsteroidal antiinflammatory drugs
Chapter 54: Systemic glucocorticoids in rheumatology
Chapter 55: Nonimmunosuppressive disease-modifying antirheumatic drugs
Chapter 56: Methotrexate
Chapter 57: Leflunomide
Chapter 58: Immunosuppressives: Cyclosporine, cyclophosphamide, azathioprine, mycophenolate mofetil
Chapter 59: T-cell costimulation and other directed therapies
Chapter 60: B-cell depletion
Chapter 61: Cytokine neutralizers: Interleukin-1 inhibitors
Chapter 62: Interleukin-6 inhibition
Chapter 63: Tumor necrosis factor–blocking therapies
Chapter 64: Kinase inhibition: A new therapeutic principle in rheumatology
Chapter 65: Emerging therapeutic targets: GM-CSF, IL-17, and IL-23
Chapter 66: Biosimilars in rheumatology
Chapter 67: Infections and biologic therapy for rheumatoid arthritis: An update on risk and prevention
Chapter 68: Drugs and pregnancy
Chapter 69: Aspiration and injection of joints and periarticular tissue and intralesional therapy
Chapter 70: Perioperative care of patients with rheumatic disease

SECTION 5: REGIONAL AND WIDESPREAD PAIN
Chapter 71: Neck pain
Chapter 72: Lumbar spine disorders
Chapter 73: The shoulder
Chapter 74: The elbow
Chapter 75: The wrist and hand
Chapter 76: The hip
Chapter 77: The knee
Chapter 78: The ankle and foot
Chapter 79: The temporomandibular joint
Chapter 80: Fibromyalgia and related syndromes
Chapter 81: Entrapment neuropathies and compartment syndromes
Chapter 82: Complex regional pain syndrome

SECTION 6: RHEUMATOID ARTHRITIS AND OTHER SYNOVIAL DISORDERS
Chapter 83: Classification and epidemiology of rheumatoid arthritis
Chapter 84: Preclinical features of rheumatoid arthritis
Chapter 85: Clinical features of rheumatoid arthritis
Chapter 86: Extraarticular features of rheumatoid arthritis and systemic involvement
Chapter 87: Adult-onset Still disease
Chapter 88: Imaging of rheumatoid arthritis
Chapter 89: The contribution of genetic factors to rheumatoid arthritis
Chapter 90: Animal models of arthritis
Chapter 91: Autoantibodies in rheumatoid arthritis
Chapter 92: Cellular immunity in rheumatoid arthritis
Chapter 93: Angiogenesis and vasculogenesis in rheumatoid arthritis
Chapter 94: The rheumatoid joint: Synovitis and tissue destruction
Chapter 95: Evaluation and management of early inflammatory polyarthritis
Chapter 96: Evaluation and outcomes of patients with rheumatoid arthritis
Chapter 97: Management of rheumatoid arthritis: synovitis
Chapter 98: Multidisciplinary approach to rheumatoid arthritis

SECTION 7: PEDIATRIC RHEUMATOLOGY
Chapter 99A: Evaluation of musculoskeletal complaints in children: Clinical evaluation
Chapter 99B: Evaluation of musculoskeletal complaints in children: Nonautoimmune musculoskeletal disorders
Chapter 100: Classification and epidemiology of juvenile idiopathic arthritis
Chapter 101: Clinical features of juvenile idiopathic arthritis
Chapter 102: Etiology and pathogenesis of juvenile idiopathic arthritis
Chapter 103: Management of juvenile idiopathic arthritis
Chapter 104: Juvenile-onset spondyloarthritis
Chapter 105: Connective tissue diseases in children
Chapter 106: Rehabilitation and psychosocial issues in juvenile idiopathic arthritis

SECTION 8: INFECTION-RELATED RHEUMATIC DISEASES
Chapter 107: Infectious arthritis I: Bacterial arthritis
Chapter 108: Infectious arthritis II: Mycobacterial, brucellar, fungal, and parasitic arthritis
Chapter 109: Lyme disease
Chapter 110: Rheumatologic aspects of viral infections
Chapter 111: Acute rheumatic fever
Chapter 112: Reactive arthritis

SECTION 9: SPONDYLOARTHRITIS
Chapter 113: Classification and epidemiology of spondyloarthritis
Chapter 114: Clinical features of axial spondyloarthritis
Chapter 115: Etiology, pathogenesis, and pathophysiology of ankylosing spondylitis
Chapter 116: Genetics of axial spondyloarthritis
Chapter 117: Imaging in spondyloarthritis
Chapter 118: Management of ankylosing spondylitis/axial spondyloarthritis
Chapter 119: Classification and epidemiology of psoriatic arthritis
Chapter 120: Clinical features of psoriatic arthritis
Chapter 121: Etiology and pathogenesis of psoriatic arthritis
Chapter 122: Management of psoriatic arthritis
Chapter 123: Enthesopathies

SECTION 10: CONNECTIVE TISSUE DISORDERS
Chapter 124: Epidemiology and classification of systemic lupus erythematosus
Chapter 125: Preclinical features of lupus
Chapter 126: Clinical features of systemic lupus erythematosus
Chapter 127: Genetics of lupus
Chapter 128: Immunopathology of systemic lupus erythematosus
Chapter 129: Animal models of lupus
Chapter 130: Autoantibodies in systemic lupus erythematosus
Chapter 131: Pathogenesis of lupus
Chapter 132: Drug-induced lupus
Chapter 133: Assessing disease activity and outcome in systemic lupus erythematosus
Chapter 134: Management of nonrenal and non–central nervous system lupus
Chapter 135: Treatment of neuropsychiatric lupus
Chapter 136: Systemic lupus erythematosus: treatment—renal involvement
Chapter 137: Systemic lupus erythematosus in the pregnant patient and neonatal lupus
Chapter 138: Sjögren syndrome
Chapter 139: Antiphospholipid syndrome: Overview of pathogenesis, diagnosis, and management
Chapter 140: Classification and epidemiology of scleroderma
Chapter 141: Assessing disease activity and outcome in systemic sclerosis (scleroderma)
Chapter 142: Clinical features of systemic sclerosis
Chapter 143: Etiology and pathogenesis of systemic sclerosis
Chapter 144: Management of systemic sclerosis
Chapter 145: Pulmonary management of systemic sclerosis
Chapter 146: Raynaud phenomenon
Chapter 147: Localized scleroderma and scleroderma-like syndromes
Chapter 148: Clinical features, classification, and epidemiology of inflammatory muscle disease
Chapter 149: Inflammatory muscle disease: etiology and pathogenesis
Chapter 150: Management of inflammatory muscle disease
Chapter 151: Metabolic, drug-induced, and other noninflammatory myopathies
Chapter 152: Overlap syndromes

SECTION 11: THE VASCULITIDES
Chapter 153: Classification and epidemiology of vasculitis
Chapter 154: Biology and immunopathogenesis of vasculitis
Chapter 155: Polyarteritis nodosa and Cogan syndrome
Chapter 156: Polymyalgia rheumatica and giant cell arteritis
Chapter 157: Antineutrophil cytoplasmic antibody–associated vasculitis
Chapter 158: Takayasu arteritis
Chapter 159: Behçet syndrome
Chapter 160: Kawasaki disease
Chapter 161: Henoch-Schönlein purpura/immunoglobulin-A vasculitis
Chapter 162: Cutaneous vasculitis and panniculitis
Chapter 163: Cryoglobulinemia
Chapter 164: Primary angiitis of the central nervous system

SECTION 12: OTHER SYSTEMIC ILLNESSES
Chapter 165: Monogenic autoinflammatory diseases
Chapter 166: Sarcoidosis
Chapter 167: Relapsing polychondritis
Chapter 168: Amyloidosis
Chapter 169: Digital clubbing and hypertrophic osteoarthropathy
Chapter 170: Miscellaneous arthropathies

SECTION 13: OSTEOARTHRITIS AND RELATED DISORDERS
Chapter 171: Osteoarthritis: Epidemiology and classification
Chapter 172: Local and systemic risk factors for incidence and progression of osteoarthritis
Chapter 173: Clinical features of osteoarthritis
Chapter 174: Animal models of osteoarthritis
Chapter 175: Pathogenesis and pathology of osteoarthritis
Chapter 176: Genetics of osteoarthritis
Chapter 177: Imaging of osteoarthritis
Chapter 178: Assessment of the patient with osteoarthritis and measurement of outcomes
Chapter 179: Preclinical osteoarthritis
Chapter 180: Assessment of imaging outcomes in osteoarthritis
Chapter 181: Management of osteoarthritis
Chapter 182: Diffuse idiopathic skeletal hyperostosis
Chapter 183: Neuropathic arthropathy
Chapter 184: Osteonecrosis
Chapter 185: Rare osteoarthritis: Ochronosis and Kashin-Beck disease

SECTION 14: CRYSTAL-RELATED ARTHROPATHIES
Chapter 186: Epidemiology of gout
Chapter 187: Etiology and pathogenesis of gout
Chapter 188: Clinical gout
Chapter 189: Management of gout and hyperuricemia
Chapter 190: Calcium pyrophosphate crystal–associated arthropathy
Chapter 191: Basic calcium phosphate crystal deposition disease
Chapter 192: Other crystal-related arthropathies

SECTION 15: ENDOCRINE AND HEMOGLOBIN-RELATED ARTHRITIS AND STORAGE DISEASES
Chapter 193: Rheumatoid manifestations of endocrine and lipid disease
Chapter 194: Hemophilia and von Willebrand disease
Chapter 195: Joint and bone lesions in hemoglobinopathies
Chapter 196: Hemochromatosis

SECTION 16: METABOLIC BONE DISEASE
Chapter 197: Epidemiology and classification of osteoporosis
Chapter 198: Clinical features of osteoporosis
Chapter 199: Pathophysiology of osteoporosis
Chapter 200: Biochemical markers in bone disease
Chapter 201: Management of osteoporosis
Chapter 202: Glucocorticoid-induced osteoporosis
Chapter 203: Osteomalacia and rickets
Chapter 204: Primary hyperparathyroidism: Rheumatologic manifestations and bone disease
Chapter 205: Renal osteodystrophy
Chapter 206: Paget disease of bone

SECTION 17: HERITABLE DISEASE AND TUMORS OF BONE AND CONNECTIVE TISSUE
Chapter 207: Gaucher disease
Chapter 208: Mucopolysaccharidoses
Chapter 209: Heritable connective tissue disorders
Chapter 210: Hypermobility syndrome
Chapter 211: Skeletal dysplasias
Chapter 212: Bone tumors

Title: Rheumatology
Edition: 6th edition
Authors: Marc C. Hochberg, Alan J. Silman, Josef S. Smolen, Michael E. Weinblatt, Michael H. Weisman
Language: English

PASSWORD/CONTRASEÑA: www.rinconmedico.me

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