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“Male Infertility: Understanding, Causes and Treatment”

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“Male Infertility: Understanding, Causes and Treatment”
Male infertility presents a spectrum of phenotypes often with a complex etiology. About 15% of couples worldwide suffer from infertility, and male factors contribute to roughly one third, female factors contribute to another one third, and the remaining are due to combined male and female factors. In-depth physical and physiological examinations reveal exact etiology in only a few cases, resulting in the classification of the remaining as idiopathic. Due to complex and partially understood etiology, the treatment of male infertility is not straightforward. In the cases with a defined etiology, specific treatments offer hope, but in the cases with idiopathic infertility, empirical and generalized treatments are advised often.
This puts impetus on a thorough understanding of the process of spermatogenesis and fertility to craft new avenues for infertility treatment. This book aims at providing a comprehensive coverage of male infertility. It is divided in three sections; the first section introduces the reader to spermatogenesis and male fertility to provide a reasonable understanding of spermatogenic failure and male infertility.


Part I Understanding Spermatogenesis and Male Fertility
1. Overview of the Male Reproductive System
2. Embryonic Development of the Testis
3. HPG Axis: The Central Regulator of Spermatogenesis and Male Fertility
4. Sperm Maturation in Epididymis
5. Sperm Capacitation: The Obligate Requirement for Male Fertility
6. Genomic Landscape of Human Y Chromosome and Male Infertility
7. Seminal Decline in Semen Quality in Humans Over the Last 80 years

Part II Causes of Male Infertility
8. Syndromic Forms of Male Infertility
9. Cystic Fibrosis, CFTR Gene, and Male Infertility
10. Oxidative Stress and Male Infertility
11. Obesity, Spermatogenesis, and Male Infertility
12. Sexually Transmitted Infections and Male Infertility: Old Enigma, New Insights
13. Cytogenetic Factors in Male Infertility
14. Autosomal Genes in Male Infertility
15. Sex Chromosomal Genes in Male Infertility
16. Male Infertility: An Epigenetic Perspective
17. Sperm Chromatin Compaction and Male Infertility
18. Proteomics of Male Infertility

Part III Management of Male Infertility
19. Advancing Paternal Age: The Ticking Biological Clock
20. Food, Nutrition, and Male Fertility
21. Plant Products in the Management of Male Infertility
22. Lifestyle, Fertility, and Infertility Management
23. Preserving Male Fertility
24. Specific and Generalized Treatments of Male Infertility
25. Oncofertility: Fertility Preservation in Cancer
26. Assisted Reproductive Technologies in Infertility Treatment: Opportunities and Challenges

Title: Male Infertility: Understanding, Causes and Treatment
Author: Rajender Singh, Kiran Singh
Language: English


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