CONTENIDO:
Anatomy and physiology of the gene
Genomic approaches to hematology
Regulation of gene expression, transcription, splicing, and RNA metabolism
Protein synthesis, processing, and trafficking
Protein architecture: relationship of form and function
Signaling transduction and regulation of cell metabolism
Pharmacogenomics and hematologic diseases
Hematopoietic stem cell biology
Hematopoietic microenvironment
Cell adhesion
Hematopoietic cell trafficking and chemokines
Dynamic interactions between hematopoietic stem and progenitor cells and the bone marrow: current biology of stem cell homing and mobilization
Vascular growth in heatlh and disease
Principles of cytokine signaling
Control of cell division
Cell death
Overview and compartmentalization of the immune system
B-cell development
T-cell immunity
Natural killer cell immunity
Dendritic cell biology
Complement and immunoglobulin biology
Tolerance and autoimmunity
Biology of erythropoiesis, erythroid differentiation, and maturation
Granulocytopoiesis and monocytopoiesis
Thrombocytopoiesis
Inherited forms of bone marrow failure
Aplastic anemia
Paroxysmal nocturnal hemoglobinuria
Acquried disorders of red cell, white cell, and platelet production
Pathobiology of the human erythrocyte and its hemoglobins
Approach to anemia in the adult and child
Pathophysiology of iron homeostasis
Disorders of iron homeostasis: iron deficiency and overload
Anemia of chronic diseases
Heme biosynthesis and its disorders: porphyrias and sideroblastic anemias
Megaloblastic anemias
Thalassemia syndromes
Pathobiology of sickle cell disease
Sickle cell disease: clinical features and management
Hemoglobin variants associated with hemolytic anemia, altered oxygen affinity, and methemoglobinemias
Red blood cell enzymopathies
Red blood cell membrane disorders
Autoimmune hemolytic anemia
Extrinsic nonimmune hemolytic anemias
Neurotrophilic leukocytosis, neurotropenia, monocytosis, and monocytopenia
Lymphocytosis, lymphocytopenia, hypergammaglobulinemia, and hypogammaglobulinema
Disorders of phagocyte function
Congenital disorders of lymphocyte function
Histiocytic disorders
Lysosomal storage diseases: perspectives and principles
Infections mononucleosis and other Epstein-Barr virus-associated diseases
Progress in the classification of myeloid neoplasms: clinical implications
Conventional and molecular cytogenetic basis of hemotologic malignancies
Radiation therapy in the treatment of hematologic malignancies
Pathobiology of acute myeloid leukema
Clinical mainfestations and treatment of acute myeloid leukemia
Myelodysplastic syndromes: biology and treatment
Allogenic hematopoietic stem cell transplantation for acute myeloid leukemia and myelodysplastic syndrome in adults. Acute myeloid leukemia in children
Myelodysplastic and myeloproliferative neoplasms in children
Pathobiology of acute lymphoblastic leukemia
Clinical manifestations and treatment of acute lymphoblastic leukemia in children
Acute lymphoblastic leukemia in adults
Chronic myeloid leukemia
The polycythemias
Essential thrombocythemia
Primary myelofibrosis
Eosinophilia, eosinophil-associated diseases, chronic eosinophil leukemia, and the hypereosinophilic syndromes
Mast cellls and systemic mastocytosis
Pathologic basis for the classification of non-hodgkin and hodgkin lymphomas
Origin of hodgkin lymphoma
Hodgkin lymphoma: clinical manifestations, staging, and therapy
Origin of non-Hodgkin lymphoma
Chronic lymphocytic leukemia
Hairy cell leukemia
Clinical manifestations and treatment of marginal zone lymphomas (extranodal/malt, splenic, and nodal)
Clinical manifestations, staging, and treatment of follicular lymphoma
Mantle cell lymphoma
Diagnosis and treatment of diffuse large b-cell lymphoma and Burkitt lymphoma
Virus-associated lymphoma
Malignant lymphomas in childhood
T-cell lymphomas
Plasma cell neoplasms
Waldenström macroglobulinemia and lymphoplasmacytic lymphoma
Immunoglobulin light-chain amyloidosis (primary amyloidosis)
Clinical approach to infections in the compromised host
Indwelling access devices
Nutritional issues in patients with hematologic malignancies
Psychosocial aspects of hematologic disorders
Pain management and antiemetic therapy in hematologic disorders
Palliative care
Late complications of hematologic diseases and their therapies
Overview and historical perspecitve of current cell-based therapies
Practical aspects of hematologic stem cell harvesting and mobilization
Preclinical process of cell-based therapies
Graft engineering and cell processing
Principles of cell-based genetic therapies
Mesenchymal stromal cells
T-cell therapy of hematologic diseases
Natural killer cell-based therapies
Dendritic cell therapies
Overview of hematopoietic stem cell transplantation
Indications and outcome of allogeneic hematopoietic cell transplantation for hematologic malignancies in adults
Unrelated donor hematopoietic cell transplantation
Haploidentical hematopoietic cell transplantation
Unrelated donor cord blood transplantation for hematologic malignancies
Graft-versus-host disease and graft-versus-leukemia responses
Complications after hematopoietic stem cell transplantation
Human blood group antigens and antibodies
Principles of red blood cell transfusion
Principles of platelet transfusion therapy
Human leukocyte antigen and human neutrophil antigen systems
Principles of neutrophil (granulocyte) transfusions
Principles of plasma transfusion: plasma, cryoprecipitate, albumin, and immunoglobulins. Preparation of plasma-derived and recombinant human plasma proteins
Transfusion therapy for coagulation factor deficiencies
Hemapheresis
Transfusion reactions to blood and cell therapy products
Transfusion-transmitted diseases
Transfusion medicine in hematopoietic stem cell and solid organ transplantation
Pediatric transfusion medicine
Overview of hemostasis and thrombosis
The blood vessel wall
Megakaryocyte and platelet structure
Molecular basis for platelet function
Molecular basis of blood coagulation
Regulatory mechanisms in hemostasis
Clinical approach to the patient with bleeding or bruising
Laboratory evaluation of hemostatic and thrombotic disorders
Acquired disorders of platelet function
Diseases of platelet number: immune thrombocytopenia, neonatal alloimmune thrombocytopenia, and posttransfusion purpura
Thrombocytopenia caused by platelet destruction, hypersplenism, or hemodilution
Heparin-induced thrombocytopenia
Thrombotic thrombocytopenic purpura and the hemolytic uremic syndrome
Hemophilia A and B
Inhibitors in hemophilia A and B
Rare coagulation factor deficiencies
Structure, biology, and genetics of von willebrand factor
Disseminated intravascular coagulation
Hypercoagulable states
Antiphospholipid syndrome
Venous thromboembolism
Mechanical interventions in arterial and venous thrombosis
Atherothrombosis
Stroke
Acute coronary syndromes
Atrial fibrillation
Peripheral artery disease
Antithrombotic drugs
Disorders of coagulation in the neonate
Hematologic changes in pregnancy
Hematologic manifestations of childhood illness
Hematologic manifestations of liver disease
Hematologic manifestations of systemic disease: renal disease
Hematologic manifestations of cancer
Integrative therapies in patients with hematologic diseases
Hematologic manifestations of HIV/AIDS
Hematologic aspects of parasitic diseases
Hematologic problems in the surgical patient: bleeding and thrombosis
The spleen and its disorders
Hematology in aging
Resources for the hematologist: interpretive comments and selected reference values for neonatal, pediatric, and adult populations
