The objective of the irst edition was to provide cutting-edge information on clinical practice for practicing endocrinologists and doctors training in endocrinology. The second edition retains this ethos, but it has been extensively updated and modiied. Endocrinology is moving toward an increasingly personalized approach to patient management.
This is relected by the increased focus on mechanisms of disease and biomarkers.
Certain subjects, such as neuroendocrine disease (Chapter 1), take a more generalized approach to the ield, before focusing on speciic diseases. The chapter is supported by protocols for pituitary function testing in the appendix.
Separate chapters have been assigned to pituitary radiotherapy and surgery. Other chapters are more speciically focused from the outset. There is a dedicated chapter for imaging, which has changed considerably in the past few years, particularly with the increasing use of positron emission tomography.
A major stride forward has been achieved in the ield of pituitary disease with the identiication of aryl hydrocarbon receptor–interacting protein mutations in a proportion of patients with familial isolated pituitary adenomas.
Accordingly, there is a new chapter dedicated to this topic. Neuroendocrine tumors are included for the irst time as a separate chapter, because the incidence of this disease is increasing rapidly, and endocrinologists frequently take a leading role in their management. Closely linked to neuroendocrine tumors, there is a new chapter on hereditary primary hyperparathyroidism and multiple endocrine neoplasia. New chapters on disorders in calcium regulation and genetics of infertility relect the mechanistic and genomic advances that have been made in recent times. Finally, there is a new chapter on the endocrinology of aging, focusing on the highly relevant endocrinological changes that occur in this group of individuals, who form an increasing part of the clinician’s responsibilities.
1. Neuroendocrine disease
2. Familial isolated pituitary adenomas
3. Surgical management of pituitary adenomas
4. Pituitary radiotherapy
5. Replacement therapy in adult hypopituitarism
6. IGF-I as a metabolic hormone
7. Radionuclide scanning in the diagnosis and treatment of endocrine disorders
8. Gastroenteropancreatic neuroendocrine tumors (neoplasms)
9. Hereditary primary hyperparathyroidism and multiple endocrine neoplasia
10. Coincidental adrenal masses and adrenal cancer
11. Disorders of calcium regulation
12. Metabolic bone disease
13. Autoimmune endocrine disease
14. Nonautoimmune thyroid disease
15. Differentiated and undifferentiated thyroid cancer
16. The inherited basis of hypogonadotropic hypogonadism
17. Hypogonadism, erectile dysfunction, and infertility in men
18. Amenorrhea and hirsutism
19. Endocrine problems in pregnancy
20. Fluid and electrolyte disorders
21. Endocrine hypertension
23. Endocrinology of aging
24. Endocrine emergencies
Appendix: Pituitary function testing
Title: Endocrinology in Clinical Practice
Edition: Second Edition
Authors: Philip E. Harris, Pierre-Marc G. Bouloux