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Cerebral Microbleeds Pathophysiology to Clinical Practice

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Cerebral Microbleeds Pathophysiology to Clinical Practice
Cerebrovascular diseases (including symptomatic strokes and vascular cognitive impairment) are arguably the leading cause of death and disability worldwide. About one in three symptomatic strokes are caused by diseases of small perforating arteries,
including most cases of spontaneous intracerebral hemorrhage, the most severe and lethal type of stroke. Despite the clear importance of small vessel diseases, many effective interventions (for example endovascular techniques) currently target only disease of large arteries, because small vessels are technically inaccessible and the underlying mechanisms of small vessel diseases remain relatively poorly understood.

The importance of small vessel disease is yet further increased because it is the commonest cause of socalled “silent strokes”: vascular damage to the brain seen on neuroimaging (or at autopsy) that does not cause an obvious acute stroke syndrome but may have important cumulative effects, particularly on behavior or cognition. Subclinical cerebrovascular disease is revealed by changes on MRI scans, including
white matter changes (leukoaraiosis) and small, deep infarcts (lacunes). There is increasing evidence that such silent cerebrovascular disease signifies an increased risk of symptomatic stroke, and plays a key role in cognitive impairment and dementia – perhaps the biggest challenge of all facing aging societies.


Section 1–Historical aspects, detection and interpretation
1. Historical overview:

microaneurysms, cerebral microbleeds and intracerebral Hemorrhage
2. Detection of cerebral microbleeds:
physical principles, technical aspects and newdevelopments
3. Susceptibility-weighted imaging
4. Defining and mapping cerebral
5. Cerebral microbleed mimicsmicrobleeds

Section 2–Mechanisms underlying microbleeds:
6. Histopathology of cerebral microbleeds
7. Risk factors for cerebral microbleeds
8. Relationship of cerebral microbleeds to other imaging findings

Section 3–Microbleeds in relation to specific populations, diseases and neurological symptoms:
9. Cerebral microbleeds in healthy populations
10. Cerebral microbleeds in relation to cerebrovascular disease
11. Cerebral microbleeds in relation to hypertensive arteriopathy
12. Cerebral microbleeds in relation to cerebral amyloid angiopathy
13. Cerebral microbleeds and Alzheimer’s disease
14. Cerebral microbleeds in relation to brain trauma
15. Cerebral microbleeds in CADASIL
16. Miscellaneous conditions associated with cerebral microbleeds
17. Cerebral microbleeds and cognitive impairment
18. Other clinical manifestations of cerebral microbleeds
19. Cerebral microbleeds and antithrombotic treatment
20. Cerebral microbleeds and thrombolysis

Title: Cerebral Microbleeds Pathophysiology to Clinical Practice
Author: David J.Werring
Language: English


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