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Blood Science Principles and Pathology

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Blood Science Principles and Pathology

Blood Science is a relatively new discipline which merges biochemistry, haematology, immunology, transfusion science and genetics. This bringing together of traditional disciplines requires a corresponding change in education and training for healthcare scientists and Blood Science: Principles and Pathology is written in response to this emerging need. An introduction to the subject and an overview of the techniques used in blood science are followed by a series of chapters based on groups of analytes investigated in blood – red blood cells, white blood cells and platelets, followed by the constituents of plasma, including waste products, electrolytes, glucose, lipids, enzymes, hormones, nutrients, drugs, poisons and others. Each chapter is supported by learning objectives, summaries and further information, and a focus is given to chapter specific case studies with interpretation to demonstrate how laboratory data in conjunction with clinical details is utilised when investigating patients with actual or suspected disease. Finally, a separate chapter offers more detailed case reports that integrate the different aspects of blood science. Undergraduate students taking blood science modules as part of their BSc programmes in Biomedical and Healthcare Sciences will appreciate the level of integration between clinical biochemistry and haematology. In addition, this book will provide suitable initial reading for those students embarking on blood science modules on MSc programmes and will be of value to new graduates entering the profession and starting their career in blood science departments by supplementing practice-based training with the required theoretical underpinning.

1 Introduction to Blood Science
2 Analytical Techniques in Blood Science
3 The Physiology of the Red Blood Cell
4 The Pathology of the Red Blood Cell
5 White Blood Cells in Health and Disease
6 White Blood Cell Malignancy
7 The Physiology and Pathology of Haemostasis
8 The Diagnosis and Management of Disorders of Haemostasis
9 Immunopathology
10 Immunogenetics and Histocompatibility
11 Blood Transfusion
12 Waste Products, Electrolytes and Renal Disease
13 Hydrogen Ions, pH, and Acid–Base Disorders
14 Glucose, Lipids and Atherosclerosis
15 Calcium, Phosphate, Magnesium and Bone Disease
16 Nutrients and Gastrointestinal Disorders
17 Liver Function Tests and Plasma Proteins
18 Hormones and Endocrine Disorders
19 Cancer and Tumour Markers
20 Inherited Metabolic Disorders
21 Drugs and Poisons
22 Case Reports in Blood Science
Case report 1
Anaemia, hypercalcaemia, proteinuria, myeloma
Case report 2
Diabetes, glycated haemoglobin, chronic renal failure
Case report 3
Acute kidney injury, leucocytosis, neutrophilia, viruses
Case report 4
Part 1: Obesity, colorectal cancer, CEA, hypothyroidism. Part 2: Alcoholism, raised GGT and triacylglycerols
Case report 5,
Part 1: No abnormalities. Part 2: Asthma, raised IgE. Part 3: Falling haemoglobin, rising ESR, lung cancer
Case report 6
Hypothyroidism, marginally reduced haemoglobin
Case report 7
Raised CRP, ESR, rheumatoid factor and anti-nuclear antibodies; borderline anti-dsDNA antibodies, low C3, low eGFR
and so mild renal failure, systemic lupus erythematosus
Case report 8
Normal blood results in renal transplantation
Case report 9
Falling albumin, eGFR, haemoglobin, red cell count and platelets, rising ESR, white cell count and neutrophila, CRP,
urea and creatinine, septicaemia
Case report 10
Microcytic anaemia, thrombocytopenia, lymphocytosis, abnormal LFTs, falling albumin, raised CRP, myositis with
raised CK, viruses
Case report 11
Acidosis, hyperglycaemia, diabetic ketoacidosis, acute renal injury, raised urea and creatinine
Case report 12
Low haemoglobin, thrombocytopenia, raised CRP and d-dimers, abnormal LFTs, malaria, pregnancy
Case report 13
Raised aldosterone, hypernatraemia, hypokalaemia, Conn’s syndrome
Case report 14
Paediatric diabetic ketoacidosis, hyperglycaemia, low bicarbonate, raised phosphates, ALP and proteins

Appendix: Reference Ranges
Autores: Andrew Blann, Nessar Ahmed
Editorial: Wiley
Editorial: 1ª
Año: 2014
Páginas: 558
ISBN 978-1-118-35138-3
Idioma: Inglés

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